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Regional and sex differences in spontaneous striatal dopamine transmission
Journal of Neurochemistry ( IF 4.7 ) Pub Date : 2021-07-15 , DOI: 10.1111/jnc.15473
James N Brundage 1 , Colin P Mason 1 , Hillary A Wadsworth 1 , Chris S Finuf 2 , Josh J Nelson 1 , P Joakim W Ronström 1 , Sara R Jones 3 , Cody A Siciliano 4 , Scott C Steffensen 2 , Jordan T Yorgason 1, 5
Affiliation  

Striatal dopamine release is key for learning and motivation and is composed of subregions including the dorsal striatum (DS), nucleus accumbens core, and the nucleus accumbens shell. Spontaneously occurring dopamine release was compared across these subregions. Dopamine release/uptake dynamics differ across striatal subregions, with dopamine transient release amplitude and release frequency greatest in male mice, and the largest signals observed in the DS. Surprisingly, female mice exhibited little regional differences in dopamine release for DS and nucleus accumbens core regions, but lower release in the nucleus accumbens shell. Blocking voltage-gated K+ channel (Kv channels) with 4-aminopyridine enhanced dopamine detection without affecting reuptake. The 4-aminopyridine effects were greatest in ventral regions of female mice, suggesting regional differences in Kv channel expression. The dopamine transporter blocker cocaine also enhanced detection across subregions in both sexes, with greater overall increased release in females than males. Thus, sex differences in dopamine transmission are apparent and likely include differences in the Kv channel and dopamine transporter function. The lack of regional differences in dopamine release observed in females indicates differential regulation of spontaneous and evoked dopamine release.

中文翻译:

自发纹状体多巴胺传递的区域和性别差异

纹状体多巴胺的释放对于学习和动机至关重要,由背侧纹状体 (DS)、伏隔核核心和伏隔核壳等亚区域组成。比较了这些次区域自发发生的多巴胺释放。不同纹状体亚区域的多巴胺释放/摄取动态有所不同,雄性小鼠中多巴胺瞬时释放幅度和释放频率最大,而 DS 中观察到的信号最大。令人惊讶的是,雌性小鼠在 DS 和伏核核心区域的多巴胺释放方面表现出很小的区域差异,但在伏核壳中释放较低。用 4-氨基吡啶阻断电压门控 K +通道(Kv 通道)可增强多巴胺检测,而不影响再摄取。4-氨基吡啶对雌性小鼠腹侧区域的影响最大,表明 Kv 通道表达存在区域差异。多巴胺转运蛋白阻断剂可卡因也增强了男女各次区域的检测,女性释放量总体增加量高于男性。因此,多巴胺传递的性别差异是明显的,并且可能包括 Kv 通道和多巴胺转运蛋白功能的差异。在女性中观察到的多巴胺释放缺乏区域差异表明自发性和诱发性多巴胺释放的差异调节。
更新日期:2021-07-15
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