Piezoelectric biomaterials are intrinsically suitable for coupling mechanical and electrical energy in biological systems to achieve in vivo real-time sensing, actuation, and electricity generation. However, the inability to synthesize and align the piezoelectric phase at a large scale remains a roadblock toward practical applications. We present a wafer-scale approach to creating piezoelectric biomaterial thin films based on γ-glycine crystals. The thin film has a sandwich structure, where a crystalline glycine layer self-assembles and automatically aligns between two polyvinyl alcohol (PVA) thin films. The heterostructured glycine-PVA films exhibit piezoelectric coefficients of 5.3 picocoulombs per newton or 157.5 × 10⁻³ volt meters per newton and nearly an order of magnitude enhancement of the mechanical flexibility compared with pure glycine crystals. With its natural compatibility and degradability in physiological environments, glycine-PVA films may enable the development of transient implantable electromechanical devices.

压电生物材料本质上适用于耦合生物系统中的机械能和电能，以实现体内实时传感、驱动和发电。然而，无法大规模合成和对齐压电相仍然是实际应用的障碍。我们提出了一种晶圆级方法来创建基于 γ-甘氨酸晶体的压电生物材料薄膜。该薄膜具有夹层结构，其中结晶甘氨酸层自组装并在两个聚乙烯醇 (PVA) 薄膜之间自动对齐。异质结构的甘氨酸-PVA 薄膜的压电系数为 5.3 皮库仑/牛顿或 157.5 × 10 ^-3与纯甘氨酸晶体相比，每牛顿伏特米，机械柔韧性提高了近一个数量级。凭借其在生理环境中的天然相容性和可降解性，甘氨酸-PVA 薄膜可用于开发瞬态可植入机电设备。