In this study, magnetic molecularly imprinted polymers (MMIPs) with enhanced selectivity were synthesized using sulfamethazine (SMZ) as template molecule and hydrophilic triethylene glycol dimethacrylate as cross-linker. Compared with that of imprinted polymers (MMIPs@EGDMA) prepared with commonly used ethylene glycol dimethacrylate, MMIPs with increased hydrophilicity could achieve efficient adsorption and preferred binding ability for template SMZ (selectivity factor increased from 0.9 of MMIPs@EGDMA to 1.9) in the presence of structural analogues with significant similarities (i.e. sulfamonomethoxine). Under the optimal extraction conditions, the developed MMIPs-MSPE-HPLC-DAD method showed wide linear range (1.6–250 μg/L), low detection limit (0.44 μg/L) and satisfactory precision (RSD ＜ 7%). The proposed strategy offers a potential and simple way to obtain imprinted polymers with high recognition capability, providing a perspective method in the accurate determination of SMZ in environmental water.

本研究以磺胺二甲嘧啶（SMZ）为模板分子，亲水性三甘醇二甲基丙烯酸酯为交联剂，合成了具有增强选择性的磁性分子印迹聚合物（MMIPs）。与常用的乙二醇二甲基丙烯酸酯制备的印迹聚合物（MMIPs@EGDMA）相比，亲水性增加的MMIPs在存在下可以实现对模板SMZ的高效吸附和优选结合能力（选择性因子从MMIPs@EGDMA的0.9增加到1.9）具有显着相似性的结构类似物（即磺胺间甲氧嘧啶）。在最佳提取条件下，建立的MMIPs-MSPE-HPLC-DAD方法线性范围宽（1.6-250 μg/L），检出限低（0.44 μg/L），精密度令人满意（RSD ＜ 7%）。