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Drug-release dynamics and antibacterial activities of chitosan/cefazolin coatings on Ti implants
Progress in Organic Coatings ( IF 6.6 ) Pub Date : 2021-07-16 , DOI: 10.1016/j.porgcoat.2021.106385
Shyi-Tien Chen , Hsiu-Wen Chien , Chih-Yu Cheng , Hui-Min Huang , Tzu-Yu Song , Yi-Cheng Chen , Chien-Hui Wu , Yi-Huang Hsueh , Yan-Hsiung Wang , Shih-Fu Ou

Chitosan/drug (cefazolin) coatings were synthesized on alkali-treated Ti surfaces via electrophoretic deposition to improve the antibacterial activities and corrosion resistances of the surfaces. The coatings exhibited desirable adhesion to the alkali-treated Ti due to the penetration of chitosan and drug into the pores of the substrates. The chitosan were cationic molecules which carried drug and both of them migrated toward the cathode during electrophoretic deposition. At a low potential, the drug dissolved in the chitosan film, whereas at a high potential, the drug aggregated into sheets on the surface of chitosan. The high potential provided the coating with high drug loading and releasing capacity. The total drug release of chitosan/drug coatings with 4.3 and 6.9 μm thickness in Hank's balanced salt solution (HBSS) was about 3 and more than 14 days, respectively. The coatings exhibited increased corrosion resistance than the Ti in HBSS evaluated via potentiostat. Additionally, the coating with high drug loading demonstrated approximate 100% antibacterial activities against Escherichia coli; thus, the proposed coatings can be used as promising Ti coatings to limit bacterial adhesion and proliferation.



中文翻译:

钛植入物壳聚糖/头孢唑啉涂层的药物释放动力学和抗菌活性

通过电泳沉积在碱处理的钛表面上合成壳聚糖/药物(头孢唑啉)涂层,以提高表面的抗菌活性和耐腐蚀性。由于壳聚糖和药物渗透到基材的孔中,涂层对碱处理的钛表现出理想的附着力。壳聚糖是携带药物的阳离子分子,在电泳沉积过程中它们都向阴极迁移。在低电位下,药物溶解在壳聚糖薄膜中,而在高电位下,药物在壳聚糖表面聚集成片。高电位为涂层提供了高载药量和释放量。Hank' 中厚度为 4.3 和 6.9 μm 的壳聚糖/药物包衣的总药物释放 s 平衡盐溶液 (HBSS) 分别为约 3 天和 14 天以上。通过恒电位仪评估的 HBSS 中的涂层表现出比 Ti 更高的耐腐蚀性。此外,具有高载药量的涂层表现出大约 100% 的抗菌活性大肠杆菌;因此,所提出的涂层可用作有前途的钛涂层,以限制细菌粘附和增殖。

更新日期:2021-07-16
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