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β-Hydroxybutyrate Attenuates Clinical Symptoms and Pain Behaviors in MOG-Induced Encephalomyelitis
Neurochemical Journal ( IF 0.5 ) Pub Date : 2021-07-15 , DOI: 10.1134/s1819712421020100
Vahideh Mirzaei 1 , Akram Eidi 1 , Shahrbanoo Oryan 1, 2 , Homa Manaheji 3 , Jalal Zaringhalam 3
Affiliation  

Abstract

A wide range of evidence shows that Multiple sclerosis is associated with increased nociceptive and neuropathic pain affecting the quality of life in patients. There are no effective medications to relieve pain without side effects in patients with Multiple sclerosis. Hence, there is a major need to develop new effective therapies for the treatment of chronic pain in these patients. Emerging evidence suggests that β-hydroxybutyrate, the most abundant ketone body metabolite, is able to relieve pain in experimental animals. In the current study, the therapeutic effects of β-hydroxybutyrate on clinical symptoms and pain behaviors were investigated in an animal model of multiple sclerosis (experimental autoimmune encephalomyelitis; EAE). Clinical scores and body weight were recorded in EAE-induced female C57BL6 mice. To measure pain behaviors, animals were subjected to three tests including Radiant heat, Mechano-allodynia, and tail flick before and after EAE induction. The findings indicated that β-hydroxybutyrate significantly attenuated clinical scores and pain behaviors in EAE-induced mice. However, we did not any significant changes in body weight of EAE-induced mice. Overall, this study suggests that β-hydroxybutyrate could be used as a therapeutic agent for the treatment of clinical symptoms and pain behaviors in mice with EAE. Further studies are needed to validate these findings in humans.



中文翻译:

β-羟基丁酸减轻 MOG 诱导的脑脊髓炎的临床症状和疼痛行为

摘要

大量证据表明,多发性硬化症与伤害性和神经性疼痛增加有关,影响患者的生活质量。没有有效的药物可以缓解多发性硬化症患者的疼痛而不产生副作用。因此,迫切需要开发新的有效疗法来治疗这些患者的慢性疼痛。新出现的证据表明,β-羟基丁酸是最丰富的酮体代谢物,能够缓解实验动物的疼痛。在目前的研究中,β-羟基丁酸对多发性硬化症(实验性自身免疫性脑脊髓炎;EAE)动物模型的临床症状和疼痛行为的治疗作用进行了研究。在 EAE 诱导的雌性 C57BL6 小鼠中记录临床评分和体重。为了测量疼痛行为,动物在 EAE 诱导前后接受了三项测试,包括辐射热、机械异常性疼痛和甩尾。研究结果表明,β-羟基丁酸盐可显着降低 EAE 诱导小鼠的临床评分和疼痛行为。然而,EAE 诱导的小鼠的体重没有任何显着变化。总体而言,这项研究表明 β-羟基丁酸盐可用作治疗 EAE 小鼠临床症状和疼痛行为的治疗剂。需要进一步的研究来验证这些在人类中的发现。EAE 诱导小鼠的体重没有任何显着变化。总体而言,这项研究表明 β-羟基丁酸盐可用作治疗 EAE 小鼠临床症状和疼痛行为的治疗剂。需要进一步的研究来验证这些在人类中的发现。EAE 诱导小鼠的体重没有任何显着变化。总体而言,这项研究表明 β-羟基丁酸盐可用作治疗 EAE 小鼠临床症状和疼痛行为的治疗剂。需要进一步的研究来验证这些在人类中的发现。

更新日期:2021-07-16
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