Abstract—Intermediate memory is one of the stages in the process of memory consolidation and completely disappears by the beginning of the appearance of long-term memory. This stage depends on translation but not transcription, and is also accompanied by the activation of protein synthesis. RNA modifications called epitranscriptome, especially N6-methyladenosine (m6A) methylation, may be involved in the regulation of this process. Numerous studies showed a general translation-stimulating effect of m6A and an increase in the amount of this modification in mRNA of animal neurons after training. Modulation of individual enzymes associated with m6A resulted in both impairment and enhancement of memory consolidation. In this review, a hypothetical model of their participation in memory consolidation is put forward on the basis of data on changes in the RNA of m6A methylome and the behavior of FTO demethylase in neurons of trained animals. In addition, other epigenetic and epitranscriptome mechanisms that potentially regulate this process are considered.

摘要——中级记忆是记忆巩固过程中的一个阶段，在长时记忆出现时完全消失。这个阶段依赖于翻译而不是转录，还伴随着蛋白质合成的激活。称为表观转录组的 RNA 修饰，尤其是 N6-甲基腺苷 (m6A) 甲基化，可能参与了这一过程的调控。大量研究表明，m6A 具有普遍的翻译刺激作用，并且在训练后动物神经元 mRNA 中这种修饰的数量增加。与 m6A 相关的单个酶的调节导致记忆巩固的损害和增强。在这次审查中，基于 m6A 甲基化组的 RNA 变化和受过训练的动物神经元中 FTO 去甲基化酶行为的数据，提出了它们参与记忆巩固的假设模型。此外，还考虑了可能调节该过程的其他表观遗传和表观转录组机制。