Bacterial infection is an acute infection caused by pathogens or conditional pathogens, which leads to severe disease and even death. It has become a significant reason for diseases and deaths worldwide. Therefore, rapid and precise detection, diagnosis, and treatment in the early stage are the key to deal with bacterial infections. Over recent years, along with the advances in biomaterials and nanotechnology, numerous nanomaterial-based multifunctional probes have been extensively explored in the biomedical field. Because of their excellent optical properties, inorganic optical nanoprobes are used to rapidly detect bacterial infection in the early stage and show excellent antibacterial properties, which has a great application prospect in antibacterial therapy expected to reduce the risk of bacterial infection. In this mini-review, we generally overviewed and summarized recent progress on inorganic nanoparticle-based optical imaging techniques as a platform to construct functional theranostics for the efficient treatment of bacterial infections. The opportunities and challenges in the application of fluorescent optical nanoprobes are prospected.

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无机光学纳米探针在细菌感染中的应用

细菌感染是由病原体或条件性病原体引起的急性感染，导致病情严重甚至死亡。它已成为全球疾病和死亡的重要原因。因此，早期快速精准的检测、诊断和治疗是应对细菌感染的关键。近年来，随着生物材料和纳米技术的进步，许多基于纳米材料的多功能探针在生物医学领域得到了广泛的探索。由于其优异的光学性能，无机光学纳米探针用于早期快速检测细菌感染并显示出优异的抗菌性能，在有望降低细菌感染风险的抗菌治疗中具有巨大的应用前景。在这个迷你评论中，我们总体上概述和总结了基于无机纳米粒子的光学成像技术的最新进展，作为构建功能性治疗诊断学以有效治疗细菌感染的平台。展望了荧光光学纳米探针在应用中的机遇和挑战。