Impulse control disorders (ICD) in Parkinson’s disease (PD) might be attributed to misestimate of rewards or the failure to curb inappropriate choices. The mechanisms underlying ICD were reported to involve the lateralization of monoamine network. Our objective was to probe the significant role of lateralization in the pathogenesis of ICD. Twenty-one PD patients with ICD (PD-ICD), thirty-three without ICD (PD-no ICD), and thirty-seven healthy controls (HCs) were recruited and performed T1-weighted, diffusion tensor imaging (DTI) scans and resting state functional magnetic resonance imaging (rs-fMRI). By applying the Voxel-mirrored Homotopic Connectivity (VMHC) and Freesurfer, we evaluated participants’ synchronicity of functional connectivity and structural changes between hemispheres. Also, tract-based spatial statistics (TBSS) was applied to compare fiber tracts differences. Relative to PD-no ICD group, PD-ICD group demonstrated reduced VMHC values in middle frontal gyrus (MFG). Compared to HCs, PD-ICD group mainly showed decreased VMHC values in MFG, middle and superior orbital frontal gyrus (OFG), inferior frontal gyrus (IFG) and caudate, which were related to reward processing and inhibitory control. The severity of impulsivity was negatively correlated with the mean VMHC values of MFG in PD-ICD group. Receiver operating characteristic (ROC) curves analyses uncovered that the mean VMHC values of MFG might be a potential marker identifying PD-ICD patients. However, we found no corresponding asymmetrical alteration in cortical thickness and no significant differences in fractional anisotropy (FA) and mean diffusivity (MD). Our results provided further evidence for asymmetry of functional connectivity in mesolimbic reward and response inhibition network in ICD.

帕金森病 (PD) 中的冲动控制障碍 (ICD) 可能归因于对奖励的错误估计或未能遏制不适当的选择。据报道，ICD 的机制涉及单胺网络的侧化。我们的目标是探讨单侧化在 ICD 发病机制中的重要作用。招募了 21 名患有 ICD (PD-ICD) 的 PD 患者，33 名没有 ICD (PD-no ICD) 和 37 名健康对照 (HC) 并进行了 T1 加权扩散张量成像 (DTI) 扫描和静息状态功能磁共振成像（rs-fMRI）。通过应用体素镜像同伦连接 (VMHC) 和 Freesurfer，我们评估了参与者功能连接和半球之间结构变化的同步性。还，应用基于束的空间统计（TBSS）来比较纤维束的差异。相对于 PD-no ICD 组，PD-ICD 组表现出中额叶回 (MFG) 的 VMHC 值降低。与HCs相比，PD-ICD组主要表现为MFG、眶额中回（OFG）、额下回（IFG）和尾状核的VMHC值降低，这与奖赏处理和抑制控制有关。冲动的严重程度与PD-ICD组MFG的平均VMHC值呈负相关。受试者工作特征 (ROC) 曲线分析表明，MFG 的平均 VMHC 值可能是识别 PD-ICD 患者的潜在标志物。然而，我们发现皮质厚度没有相应的不对称改变，分数各向异性 (FA) 和平均扩散率 (MD) 也没有显着差异。