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Serum lipid profile among sporadic and familial forms of Parkinson’s disease
npj Parkinson's Disease ( IF 9.304 ) Pub Date : 2021-07-16 , DOI: 10.1038/s41531-021-00206-6
Daniel Macías-García 1, 2 , María Teresa Periñán 1, 2 , Laura Muñoz-Delgado 1, 2 , María Valle Jimenez-Jaraba 1 , Miguel Ángel Labrador-Espinosa 1, 2, 3 , Silvia Jesús 1, 2 , Dolores Buiza-Rueda 1, 2 , Carlota Méndez-Del Barrio 1 , Astrid Adarmes-Gómez 1, 2 , Pilar Gómez-Garre 1, 2 , Pablo Mir 1, 2, 3
Affiliation  

Brain cholesterol metabolism has been described as altered in Parkinson’s disease (PD) patients. Serum lipid levels have been widely studied in PD with controversial results among different populations and age groups. The present study is aimed at determining if the serum lipid profile could be influenced by the genetic background of PD patients. We included 403 PD patients (342 sporadic PD patients, 30 GBA-associated PD patients, and 31 LRRK2-associated PD patients) and 654 healthy controls (HCs). Total cholesterol, HDL, LDL, and triglycerides were measured in peripheral blood. Analysis of covariance adjusting for sex and age (ANCOVA) and post hoc tests were applied to determine the differences within lipid profiles among the groups. Multivariate ANCOVA revealed significant differences among the groups within cholesterol and LDL levels. GBA-associated PD patients had significantly lower levels of total cholesterol and LDL compared to LRRK2-associated PD patients and HCs. The different serum cholesterol levels in GBA-associated PD might be related to diverse pathogenic mechanisms. Our results support the hypothesis of lipid metabolism disruption as one of the main PD pathogenic mechanisms in patients with GBA-associated PD. Further studies would be necessary to explore their clinical implications.



中文翻译:

散发性和家族性帕金森病的血清脂质谱

据描述,帕金森病 (PD) 患者的大脑胆固醇代谢发生了改变。帕金森病中的血清脂质水平已被广泛研究,不同人群和年龄组的结果存在争议。本研究旨在确定帕金森病患者的遗传背景是否会影响血清脂质谱。我们纳入了 403 名 PD 患者(342 名散发性 PD 患者、30 名GBA相关 PD 患者和 31 名LRRK2相关 PD 患者)和 654 名健康对照 (HC)。测量外周血中的总胆固醇、HDL、LDL 和甘油三酯。应用性别和年龄的协方差调整分析(ANCOVA)和事后检验来确定各组之间血脂谱的差异。多变量方差分析显示各组之间胆固醇和低密度脂蛋白水平存在显着差异。与LRRK2相关的 PD 患者和 HC相比,GBA相关的 PD 患者的总胆固醇和 LDL 水平显着降低。GBA相关PD的不同血清胆固醇水平可能与不同的致病机制有关。我们的结果支持脂质代谢紊乱是GBA相关 PD患者主要 PD 致病机制之一的假设。需要进一步的研究来探索它们的临床意义。

更新日期:2021-07-16
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