The rapid development of COVID-19 vaccines and their deployment in less than a year is a scientific and medical triumph that has raised a key question. Why do we have several SARS-CoV-2 vaccines but do not have a single HIV-1 vaccine? It took roughly 1 year for a COVID-19 vaccine to become available, yet, four decades after the first patient with HIV was described, we do not yet have a vaccine for HIV. Here, Barton Haynes examines the biological reasons why vaccine development for HIV is so exceptionally challenging.

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SARS-CoV-2 和 HIV-1——两种疫苗的故事

COVID-19 疫苗的快速开发及其在不到一年的时间内部署是一项科学和医学上的胜利，它提出了一个关键问题。为什么我们有几种 SARS-CoV-2 疫苗，但没有一种 HIV-1 疫苗？大约需要 1 年时间才能获得 COVID-19 疫苗，然而，在第一个 HIV 患者被描述后的 40 年，我们还没有 HIV 疫苗。在这里，巴顿·海恩斯 (Barton Haynes) 研究了 HIV 疫苗开发如此具有挑战性的生物学原因。