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Prospective association of maternal psychosocial stress in pregnancy with newborn hippocampal volume and implications for infant social-emotional development
Neurobiology of Stress ( IF 5 ) Pub Date : 2021-07-16 , DOI: 10.1016/j.ynstr.2021.100368
Nora K Moog 1 , Saara Nolvi 1, 2 , Theresa S Kleih 1, 3 , Martin Styner 4 , John H Gilmore 5 , Jerod M Rasmussen 6 , Christine M Heim 1, 7 , Sonja Entringer 1, 6, 8 , Pathik D Wadhwa 6, 8, 9 , Claudia Buss 1, 6, 8
Affiliation  

Maternal psychosocial stress during pregnancy can impact the developing fetal brain and influence offspring mental health. In this context, animal studies have identified the hippocampus and amygdala as key brain regions of interest, however, evidence in humans is sparse. We, therefore, examined the associations between maternal prenatal psychosocial stress, newborn hippocampal and amygdala volumes, and child social-emotional development.

In a sample of 86 mother-child dyads, maternal perceived stress was assessed serially in early, mid and late pregnancy. Following birth, newborn (aged 5–64 postnatal days, mean: 25.8 ± 12.9) hippocampal and amygdala volume was assessed using structural magnetic resonance imaging. Infant social-emotional developmental milestones were assessed at 6- and 12-months age using the Bayley-III.

After adjusting for covariates, maternal perceived stress during pregnancy was inversely associated with newborn left hippocampal volume (β = −0.26, p = .019), but not with right hippocampal (β = −0.170, p = .121) or bilateral amygdala volumes (ps > .5). Furthermore, newborn left hippocampal volume was positively associated with infant social-emotional development across the first year of postnatal life (B = 0.01, p = .011). Maternal perceived stress was indirectly associated with infant social-emotional development via newborn left hippocampal volume (B = −0.34, 95% CIBC [-0.97, −0.01]), suggesting mediation.

This study provides prospective evidence in humans linking maternal psychosocial stress in pregnancy with newborn hippocampal volume and subsequent infant social-emotional development across the first year of life. These findings highlight the importance of maternal psychosocial state during pregnancy as a target amenable to interventions to prevent or attenuate its potentially unfavorable neural and behavioral consequences in the offspring.



中文翻译:

孕期母体心理社会压力与新生儿海马体积的前瞻性关联及其对婴儿社会情绪发展的影响

怀孕期间的母亲心理社会压力会影响胎儿大脑的发育并影响后代的心理健康。在这种情况下,动物研究已将海马体和杏仁核确定为关键的大脑感兴趣区域,然而,人类的证据很少。因此,我们检查了产妇产前心理社会压力、新生儿海马和杏仁核体积以及儿童社会情绪发展之间的关联。

在一个包含 86 名母子​​的样本中,对孕早期、中期和晚期的母亲感知压力进行了连续评估。出生后,使用结构磁共振成像评估新生儿(出生后 5-64 天,平均值:25.8 ± 12.9)海马和杏仁核体积。使用 Bayley-III 在 6 个月和 12 个月大时评估婴儿的社会情感发育里程碑。

调整协变量后,孕期母体感知压力与新生儿左侧海马体积(β  = -0.26,p = .019)呈负相关,但与右侧海马体积( β  = -0.170,p  = .121)或双侧杏仁核体积无关( p s > .5)。此外,新生儿左侧海马体积与出生后第一年的婴儿社交情绪发展呈正相关(B = 0.01,p = .011)。母亲感知压力通过新生儿左侧海马体积间接与婴儿社交情绪发展相关(B = -0.34, 95% CI BC [-0.97, -0.01]),表明存在中介作用。

这项研究提供了人类的前瞻性证据,将怀孕期间母亲的社会心理压力与新生儿海马体积和随后婴儿出生后第一年的社会情绪发展联系起来。这些发现强调了孕期母体心理社会状态作为干预目标的重要性,以预防或减轻其对后代潜在的不利神经和行为后果。

更新日期:2021-07-20
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