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Differential Cognitive Performance in Females and Males with Regular Cannabis Use
Journal of the International Neuropsychological Society ( IF 2.6 ) Pub Date : 2021-07-15 , DOI: 10.1017/s1355617721000606
Ashley M Schnakenberg Martin 1, 2, 3 , Deepak Cyril D'Souza 3, 4 , Sharlene D Newman 1, 5 , William P Hetrick 1, 5, 6 , Brian F O'Donnell 1, 5, 6
Affiliation  

Objectives:Preclinical and clinical studies suggest that males and females may be differentially affected by cannabis use. This study evaluated the interaction of cannabis use and biological sex on cognition, and the association between observed cognitive deficits and features of cannabis use.Methods:Cognitive measures were assessed in those with regular, ongoing, cannabis use (N = 40; 22 female) and non-using peers (N = 40; 23 female). Intelligence, psychomotor speed, and verbal working memory were measured with the Wechsler Abbreviated Scale of Intelligence, Digit Symbol Test, and Digit Span and Hopkins Verbal Learning Test, respectively. Associations between cognitive measures and cannabis use features (e.g., lifetime cannabis use, age of initiation, time since last use of cannabis, recent high-concentration tetrahydrocannabinoid exposure) were also evaluated.Results:No main effects of group were observed across measures. Significant interactions between group and biological sex were observed on measures of intelligence, psychomotor speed, and verbal learning, with greatest group differences observed between males with and without regular cannabis use. Psychomotor performance was negatively correlated with lifetime cannabis exposure. Female and male cannabis use groups did not differ in features of cannabis use.Conclusions:Findings suggest that biological sex influences the relationship between cannabis and cognition, with males potentially being more vulnerable to the neurocognitive deficits related to cannabis use.

中文翻译:

经常使用大麻的女性和男性的认知表现差异

目标:临床前和临床研究表明,男性和女性可能受到大麻使用的不同影响。本研究评估了大麻使用和生物性别对认知的相互作用,以及观察到的认知缺陷与大麻使用特征之间的关联。方法:在那些经常、持续使用大麻的人中评估了认知措施(ñ= 40; 22 名女性)和不使用的同龄人(ñ= 40; 23 名女性)。智力、精神运动速度和言语工作记忆分别用韦氏智力缩写量表、数字符号测试、数字跨度和霍普金斯语言学习测试进行测量。还评估了认知测量与大麻使用特征(例如,终生使用大麻、开始使用大麻的年龄、自上次使用大麻以来的时间、最近的高浓度四氢大麻素暴露)之间的关联。结果:跨测量未观察到组的主要影响。在智力、精神运动速度和语言学习方面观察到群体和生物性别之间的显着相互作用,在有和没有经常使用大麻的男性之间观察到最大的群体差异。精神运动表现与终生大麻暴露呈负相关。女性和男性大麻使用群体在大麻使用特征方面没有差异。结论:研究结果表明,生理性别会影响大麻和认知之间的关系,男性可能更容易受到与大麻使用相关的神经认知缺陷的影响。
更新日期:2021-07-15
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