The code of codes or metacode is a microcosm where biological layers, as well as their codes, interact together allowing the continuity of information flow in organisms by increasing biological entities’ complexity. Through this novel organic code, biological systems scale towards niches with higher informatic freedom building structures that increase the entropy in the universe. Code biology has developed a novel informational framework where biological entities strive themselves through the information flow carried out through organic codes consisting of two molecular or functional landscapes intertwined through arbitrary linkages via an adaptor whose nature is autonomous from molecular determinism. Here we will integrate genomic and epigenomic codes according to the evidence released in ENCODE (phase 3), psychENCODE and GTEx project, outlining the principles of the metacode, to address the continuous nature of biological systems and their inter-layered information flow. This novel complex metacode maps from very constrained sets of elements (i.e., regulation sites modulating gene expression) to new ones with greater freedom of decoding (i.e., a continuous cell phenotypic space). This leads to a new domain in code biology where biological systems are informatic attractors that navigate an energy metaspace through a complexity-noise balance, stalling in emergent niches where organic codes take meaning.

代码或元代码代码是生物层及其代码相互作用的缩影，通过增加生物实体的复杂性，允许生物体中信息流的连续性。通过这种新颖的有机代码，生物系统向具有更高信息自由度的生态位扩展，构建结构会增加宇宙中的熵。代码生物学已经开发出一种新的信息框架，在该框架中，生物实体通过有机代码实现的信息流自我奋斗，有机代码由两个分子或功能景观组成，通过一个适配器通过任意链接交织在一起，其性质独立于分子决定论。在这里，我们将根据 ENCODE（第 3 阶段）、psychENCODE 和 GTEx 项目中发布的证据整合基因组和表观基因组代码，概述元代码的原则，以解决生物系统的连续性及其层间信息流。这种新颖的复杂元代码从非常受限制的元素集（即，调节基因表达的调节位点）映射到具有更大解码自由度的新元素（即，连续的细胞表型空间）。这导致了代码生物学的一个新领域，其中生物系统是信息吸引子，它们通过复杂性-噪声平衡在能量元空间中导航，在有机代码有意义的新兴生态位中停滞不前。调节基因表达的调节位点）到具有更大解码自由度的新位点（即，连续的细胞表型空间）。这导致了代码生物学的一个新领域，其中生物系统是信息吸引子，它们通过复杂性-噪声平衡在能量元空间中导航，在有机代码有意义的新兴生态位中停滞不前。调节基因表达的调节位点）到具有更大解码自由度的新位点（即，连续的细胞表型空间）。这导致了代码生物学的一个新领域，其中生物系统是信息吸引子，它们通过复杂性-噪声平衡在能量元空间中导航，在有机代码有意义的新兴生态位中停滞不前。