当前位置: X-MOL 学术Bioorg. Med. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Bioorthogonal strategies for the in vivo synthesis or release of drugs
Bioorganic & Medicinal Chemistry ( IF 3.5 ) Pub Date : 2021-07-15 , DOI: 10.1016/j.bmc.2021.116310
Boris Lozhkin 1 , Thomas R Ward 1
Affiliation  

The site-specific delivery of antitumor agents is a rapidly developing field that relies on prodrug activation and uncaging strategies. For this purpose, a wide range of homogeneous and heterogeneous biocompatible activators/catalysts have been developed to convert caged drugs with low toxicity and high stability in physiological settings into active substances in a bioorthogonal manner. The current methods allow for the site-specific delivery of activators and prodrugs to organelles, target cells, or tumors in living organisms. Here, we present an overview of the latest advances in catalytic drugs, highlighting the expanding toolbox of bioorthogonal activation strategies made possible by transition metals acting as activators or catalysts.



中文翻译:

体内合成或药物释放的生物正交策略

抗肿瘤药物的位点特异性递送是一个快速发展的领域,它依赖于前药激活和解笼锁策略。为此,已经开发了多种同质和异质生物相容性活化剂/催化剂,以生物正交方式将在生理环境中具有低毒性和高稳定性的笼状药物转化为活性物质。目前的方法允许将激活剂和前药定点递送至活生物体的细胞器、靶细胞或肿瘤。在这里,我们概述了催化药物的最新进展,重点介绍了过渡金属作为活化剂或催化剂使生物正交活化策略的扩展工具箱成为可能。

更新日期:2021-08-05
down
wechat
bug