3D-printed titanium implant combined with interleukin 4 regulates ordered macrophage polarization to promote bone regeneration and angiogenesis.,Bone & Joint Research

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3D-printed titanium implant combined with interleukin 4 regulates ordered macrophage polarization to promote bone regeneration and angiogenesis.
Bone & Joint Research ( IF 4.6 ) Pub Date : 2021-7-15 , DOI: 10.1302/2046-3758.107.bjr-2020-0334.r4
Da-Wang Zhao _{1,

2,

3} , Bing Ren _{4,

5,

6} , Hong-Wei Wang _{4,

5} , Xiao Zhang _{4,

5} , Ming-Zhi Yu _{4,

5} , Lei Cheng ₁ , Yuan-Hua Sang ₇ , Shuai-Shuai Cao _{8,

9} , Florian M Thieringer _{8,

9} , Dong Zhang _{3,

10} , Yi Wan _{4,

5} , Chao Liu _{3,

10}

Affiliation

Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, China.
Cheeloo College of Medicine, Shandong University, Jinan, China.
Institute of Stomatology, Shandong University, Jinan, Shandong, China.
Key Laboratory of High Efficiency and Clean Manufacturing, School of Mechanical Engineering, Shandong University, Jinan, China.
National Demonstration Center for Experimental Mechanical Engineering Education, School of Mechanical Engineering, Shandong University, Jinan, China.
Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida, USA.
State Key Laboratory of Crystal Materials, Shandong University, Jinan, Shandong, China.
Medical Additive Manufacturing Research Group, Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
Department of Oral and Cranio-Maxillofacial Surgery, University Hospital Basel, Basel, Switzerland.
Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan, China.

The use of 3D-printed titanium implant (DT) can effectively guide bone regeneration. DT triggers a continuous host immune reaction, including macrophage type 1 polarization, that resists osseointegration. Interleukin 4 (IL4) is a specific cytokine modulating osteogenic capability that switches macrophage polarization type 1 to type 2, and this switch favours bone regeneration.

中文翻译：

3D 打印钛植入物结合白细胞介素 4 调节有序巨噬细胞极化以促进骨再生和血管生成。

使用 3D 打印钛植入物 (DT) 可以有效引导骨骼再生。DT 触发持续的宿主免疫反应，包括抗骨整合的巨噬细胞 1 型极化。白细胞介素 4 (IL4) 是一种特定的细胞因子，可调节成骨能力，可将 1 型巨噬细胞极化转换为 2 型，这种转换有利于骨再生。

更新日期：2021-07-16

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