A new synthesis of 3-oxo-28-hydroxylup-20(29)-ene from the available natural triterpenoid betulin was developed. α,ω-Diketodiesters were prepared for the first time by different methods from 3-oxo-28-hydroxylup-20(29)-ene and a series of natural dicarboxylic acids. Steglich reaction conditions gave the highest yields. One of the synthesized α,ω-diketodiesters was moderately active in vitro against A-549 lung carcinoma.

中文翻译：

---

从桦木脑合成α,ω-二酮二酯

开发了一种从可用的天然三萜类桦木脑合成 3-oxo-28-hydroxylup-20(29)-ene 的新合成方法。α,ω-二酮二酯是首次通过不同的方法从 3-oxo-28-hydroxylup-20(29)-ene 和一系列天然二羧酸制备。Steglich 反应条件给出了最高的产率。合成的 α,ω-二酮二酯之一在体外对 A-549 肺癌具有中等活性。