Polyvinyl alcohol (PVA) hydrogel was modified with NIPAAm via a green, efficient, and industrially applicable photo induced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization catalyzed by organic dye. The hydrophilicity of PVA-g-pNIPAAm became temperature sensitive due to the introduction of pNIPAAm polymer brushes. It was surprising that PVA-g-pNIPAAm became superhydrophilic (WCA = 4.3°) at 25°C while the grafting yield was 39.3%. In addition, no cytotoxic for primary human eyelid fibroblast cells was observed according to ISO 10993.5:2009. Antifouling properties of PVA-g-pNIPAAm were significantly improved due to the increase of surface steric repulsion effect. Drug release property of PVA-g-pNIPAAm was more controllable than PVA hydrogel. Thus, organic dye catalyzed PET-RAFT polymerization could be applied to construct functional surface on biomaterials, and PVA-g-pNIPAAm hydrogel with lower cytotoxic, higher antifouling, and drug release properties had great potential in drug delivery.

中文翻译：

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通过有机染料光催化 PET-RAFT 聚合接枝 N-异丙基丙烯酰胺改善聚乙烯醇水凝胶的防污和药物输送性能

聚乙烯醇 (PVA) 水凝胶通过有机染料催化的绿色、高效和工业适用的光诱导电子转移可逆加成断裂链转移 (PET-RAFT) 聚合用 NIPAAm 改性。由于 pNIPAAm 聚合物刷的引入，PVA-g-pNIPAAm 的亲水性变得对温度敏感。令人惊讶的是，PVA-g-pNIPAAm 在 25°C 变得超亲水（WCA = 4.3°），而接枝率为 39.3%。此外，根据 ISO 10993.5:2009，未观察到对原代人眼睑成纤维细胞具有细胞毒性。由于表面空间排斥效应的增加，PVA-g-pNIPAAm的防污性能显着提高。PVA-g-pNIPAAm的药物释放特性比PVA水凝胶更可控。因此，