ABSTRACT

Objective

To evaluate the genetic variant in the macrophage migration inhibitory factor (MIF) −173 G/C in patients with schizophrenia (SCZ) by comparing genotype distributions of MIF −173 G/C between patients and healthy controls considering clinical parameters.

Methods

A sample of 118 patients with SCZ and 100 healthy volunteers were included in the study. The patients were evaluated with some scales in terms of clinical features (symptom severity, level of insight, age of onset, and treatment resistance). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine gene polymorphism.

Results

There was a statistically significant difference between the allele frequency (G, C) distributions of SCZ patients with early- and adult-onset. The C allele frequency was significantly higher in SCZ patients with early-onset (p = .033). According to the impairment of insight, we observed statistically significant differences in genotype (GG, GC, CC) distributions between SCZ patients with good and poor insight. SCZ patients with poor insight had a higher GG genotype frequency than SCZ patients with good insight (p = .021). Again, there was a statistically significant difference between genotype groups (GG, GC/CC) regarding the age of illness onset (p = .037) and schedule for assessing the three components of insight (SATCI) score (p = .005). While the age of onset of SCZ was significantly earlier in patients with the GC/CC genotype, SATCI scores of SCZ patients with the GG genotype were significantly lower than SCZ patients with GC/CC genotype.

Conclusions

MIF −173 G/C polymorphism may be associated with the age of illness onset and impairment of insight in SCZ.

中文翻译：

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巨噬细胞迁移抑制因子 - 173 G/C 多态性与土耳其人群精神分裂症的发病年龄和洞察力有关

摘要

客观的

考虑临床参数，通过比较患者和健康对照之间MIF -173 G/C的基因型分布，评估精神分裂症 (SCZ) 患者巨噬细胞迁移抑制因子 ( MIF ) -173 G/C 的遗传变异。

方法

该研究包括 118 名 SCZ 患者和 100 名健康志愿者的样本。根据临床特征（症状严重程度、洞察力水平、发病年龄和治疗抵抗力）对患者进行了一些量表评估。聚合酶链反应-限制性片段长度多态性（PCR-RFLP）用于确定基因多态性。

结果

早发和成人发病的 SCZ 患者的等位基因频率 (G, C) 分布存在统计学显着差异。早发性 SCZ 患者的 C 等位基因频率显着较高 (p = .033)。根据洞察力的损害，我们观察到具有良好和较差洞察力的 SCZ 患者的基因型（GG、GC、CC）分布存在统计学上的显着差异。洞察力差的 SCZ 患者的 GG 基因型频率高于洞察力良好的 SCZ 患者 (p = .021)。同样，基因型组 (GG, GC/CC) 在发病年龄 (p = .037) 和评估洞察力三个组成部分 (SATCI) 评分的时间表 (p = .005) 方面存在统计学显着差异。虽然 GC/CC 基因型患者的 SCZ 发病年龄明显更早，

结论

MIF -173 G/C 多态性可能与 SCZ 的发病年龄和洞察力受损有关。