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The cardiac toxicity of radiotherapy – a review of characteristics, mechanisms, diagnosis, and prevention
International Journal of Radiation Biology ( IF 2.6 ) Pub Date : 2021-07-28 , DOI: 10.1080/09553002.2021.1956007
Tianhui Wei 1 , Yufeng Cheng 1
Affiliation  

Abstract

Purpose

Radiation-induced heart disease (RIHD) is one of the most serious complications of radiotherapy. The purpose of this paper is to review recent researches about cardiac toxicity of radiotherapy in clinical characteristics, mechanisms, diagnosis, and prevention.

Conclusions

Powered by the rapid development of medicine, the overall survival (OS) of cancer has been improved significantly. Surgery, chemotherapy, and radiotherapy (RT) are three critical ways in the comprehensive treatments of cancer. There is a consensus that early diagnosis and interventions for the prevention of RIHD are crucial. This review concludes recent clinical and experimental studies on RIHD. RIHD, a heterogeneous and serious disease, is a spectrum of heart disease including myocardial disease, pericarditis, coronary artery disease, valvular heart disease, and conduction system dysfunction. Mean heart dose, biomarkers, and detecting techniques are important components in detecting heart injury. Improvements in radiotherapy regimens remain the primary goal of prevention. Further investigation is needed beyond the observation period of most of these studies.



中文翻译:

放疗的心脏毒性——特征、机制、诊断和预防综述

摘要

目的

放射诱发的心脏病 (RIHD) 是放射治疗最严重的并发症之一。本文旨在综述近年来放疗心脏毒性的临床特点、机制、诊断和预防等方面的研究进展。

结论

在医学快速发展的推动下,癌症的总生存率(OS)得到了显着提高。手术、化疗和放疗(RT)是癌症综合治疗的三种关键方式。共识是早期诊断和干预对预防 RIHD 至关重要。本综述总结了最近关于 RIHD 的临床和实验研究。RIHD 是一种异质性和严重的疾病,是一系列心脏病,包括心肌病、心包炎、冠状动脉疾病、瓣膜性心脏病和传导系统功能障碍。平均心脏剂量、生物标志物和检测技术是检测心脏损伤的重要组成部分。放射治疗方案的改进仍然是预防的主要目标。

更新日期:2021-09-28
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