Reactive oxygen species (ROS) are highly reactive molecules produced in cells. So far, they have mostly been connected to diseases and pathological conditions. More recent results revealed a somewhat unexpected role of ROS in control of developmental processes. In this review, we elaborate on ROS in development, focussing on their connection to epithelial tissue morphogenesis. After briefly summarising unique characteristics of epithelial cells, we present some characteristic features of ROS species, their production and targets, with a focus on proteins important for epithelial development and function. Finally, we provide examples of regulation of epithelial morphogenesis by ROS, and also of developmental genes that regulate the overall redox status. We conclude by discussing future avenues of research that will further elucidate ROS regulation in epithelial development.

中文翻译：

---

活性氧 (ROS) 是调节上皮发育的另一个参与者

活性氧 (ROS) 是细胞中产生的高活性分子。到目前为止，它们大多与疾病和病理状况有关。最近的结果揭示了 ROS 在控制发育过程中的一些意想不到的作用。在这篇综述中，我们详细介绍了 ROS 的发展过程，重点是它们与上皮组织形态发生的联系。在简要总结上皮细胞的独特特征后，我们介绍了 ROS 种类、它们的产生和目标的一些特征，重点是对上皮发育和功能很重要的蛋白质。最后，我们提供了 ROS 调节上皮形态发生的例子，以及调节整体氧化还原状态的发育基因的例子。