Significance: The light dose in photodynamic therapy (PDT) has a considerable influence on its treatment effect, and irradiance uniformity is an issue of much concern for researchers. However, achieving intelligent and personalized dosimetry adjustments remains a challenge for current PDT instruments. Aim: To meet the requirements of intelligent and personalized dosimetry adjustments for the light dose on an irregular surface, a new PDT device with its optimal control method is proposed. Approach: This research introduces a new PDT device that includes a 3D scanner, a light-emitting diode (LED) array, and a computer. The 3D scanner is proposed to generate the point cloud of the lesion and the LED array light source, and obtain the relative position and rotation parameters between them. Then, an image segmentation algorithm is used to segment the lesion point cloud into several cluster regions. Last, the current of each LED unit is adjusted separately to achieve the expected irradiance on each cluster. Results: Compared with the general light source, the optimized light source increases the effective irradiance area by 9% to 15% and improves its uniformity by ∼9 % on a human port-wine stain head model. Conclusions: The device and its optimal method may be used for optimizing the light dosimetry to realize intelligent and personalized treatment.

中文翻译：

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带 3D 扫描仪的光动力治疗设备的辐照均匀性优化

意义：光动力疗法（PDT）中的光剂量对其治疗效果有相当大的影响，辐照均匀性是研究人员非常关心的问题。然而，实现智能和个性化的剂量测定调整对于当前的 PDT 仪器来说仍然是一个挑战。目的：针对不规则表面光剂量智能个性化剂量调整的需求，提出一种具有最优控制方法的新型PDT装置。方法：本研究介绍了一种新的 PDT 设备，其中包括 3D 扫描仪、发光二极管 (LED) 阵列和计算机。建议使用3D扫描仪生成病灶点云和LED阵列光源，并获得它们之间的相对位置和旋转参数。然后，使用图像分割算法将病变点云分割为多个聚类区域。最后，单独调整每个 LED 单元的电流，以实现每个集群上的预期辐照度。结果：优化后的光源与普通光源相比，有效辐照面积增加了 9% 到 15%，在人体鲜红斑头模型上的均匀度提高了 9%。结论：该装置及其优化方法可用于优化光剂量测定，实现智能化、个性化治疗。优化的光源将有效辐照面积增加了 9% 到 15%，并将其均匀度提高了约 9% 在人类葡萄酒染色头模型上。结论：该装置及其优化方法可用于优化光剂量测定，实现智能化、个性化治疗。优化的光源将有效辐照面积增加了 9% 到 15%，并将其均匀度提高了约 9% 在人类葡萄酒染色头模型上。结论：该装置及其优化方法可用于优化光剂量测定，实现智能化、个性化治疗。