The development of complex forms of multicellular organisms depends on the spatial arrangement of cellular architecture and functions. The interior design of the cell is patterned by spatially biased distributions of molecules and biochemical reactions in the cytoplasm and/or on the plasma membrane. In recent years, a dynamic change in the cytoplasmic fluid flow has emerged as a key physical process of driving long-range transport of molecules to particular destinations within the cell. Here, recent experimental advances in the understanding of the generation of the various types of cytoplasmic flows and contributions to intracellular patterning are reviewed with a particular focus on feedback mechanisms between the mechanical properties of fluid flow and biochemical signaling during animal cell polarization.

多细胞生物的复杂形式的发展取决于细胞结构和功能的空间排列。细胞的内部设计由分子的空间偏向分布和细胞质和/或质膜上的生化反应形成图案。近年来，细胞质流体流动的动态变化已成为推动分子远程运输到细胞内特定目的地的关键物理过程。在这里，回顾了在理解各种类型的细胞质流动的产生和对细胞内模式的贡献方面的最新实验进展，特别关注动物细胞极化过程中流体流动的机械特性和生化信号传导之间的反馈机制。