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Microbiome dysbiosis and epigenetic modulations in lung cancer: From pathogenesis to therapy
Seminars in Cancer Biology ( IF 14.5 ) Pub Date : 2021-07-15 , DOI: 10.1016/j.semcancer.2021.07.005
Faizan Haider Khan 1 , Basharat Ahmad Bhat 2 , Bashir Ahmad Sheikh 2 , Lubna Tariq 3 , Roshan Padmanabhan 4 , Jay Prakash Verma 5 , Amritesh Chandra Shukla 6 , Afshin Dowlati 7 , Ata Abbas 8
Affiliation  

The lung microbiome plays an essential role in maintaining healthy lung function, including host immune homeostasis. Lung microbial dysbiosis or disruption of the gut-lung axis can contribute to lung carcinogenesis by causing DNA damage, inducing genomic instability, or altering the host's susceptibility to carcinogenic insults. Thus far, most studies have reported the association of microbial composition in lung cancer. Mechanistic studies describing host-microbe interactions in promoting lung carcinogenesis are limited. Considering cancer as a multifaceted disease where epigenetic dysregulation plays a critical role, epigenetic modifying potentials of microbial metabolites and toxins and their roles in lung tumorigenesis are not well studied. The current review explains microbial dysbiosis and epigenetic aberrations in lung cancer and potential therapeutic opportunities.



中文翻译:

肺癌的微生物群失调和表观遗传调控:从发病机制到治疗

肺微生物组在维持健康的肺功能(包括宿主免疫稳态)方面发挥着重要作用。肺微生物失调或肠-肺轴破坏可通过引起 DNA 损伤、诱导基因组不稳定或改变宿主对致癌性损伤的易感性而导致肺癌发生。迄今为止,大多数研究都报道了肺癌中微生物组成的关联。描述宿主-微生物相互作用促进肺癌发生的机制研究是有限的。考虑到癌症是一种多方面的疾病,其中表观遗传失调起着关键作用,微生物代谢物和毒素的表观遗传修饰潜力及其在肺肿瘤发生中的作用尚未得到充分研究。

更新日期:2021-07-15
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