Poly(N-isopropylacrylamide) (PNIPAM) having lower critical solution temperature (LCST) behavior in aqueous solutions has been actively studied for various applications in nanotechnology and controlled drug delivery. In this work, a comb-coil block copolymer is synthesized with PNIPAM coil and polyethyleneimine brushes. Self-organization of the copolymer into micelle by heating and subsequent cross-linking of the part of PEI corona resulted in a unique nanocapsule (i-CLM) with hydrophilic cross-linked PEI outer shell and thermo-responsive PNIPAM inner brush. The nanocapsule appears as a vesicle-like hollow at room temperature but did into micelle-like spheres when heated. From dynamic light scattering measurement, it is revealed apparently that the nanocapsule exhibited well the swelling and the shrinking reversibly under heating and cooling and the feature is cycled repeatedly with gradual fashion under wide-range of temperature responding. The carrier property of the nanocapsule is investigated by using hydrophobic fluorophore of Nile red (NR) as a probe and it is found that the hollow of the nanocapsule is a good nano pocket to promote the growth of nanocrystals of NR.

中文翻译：

---

由类似牙刷的梳状线圈嵌段共聚物制备的具有内部热响应表面的独特纳米胶囊

聚( N-异丙基丙烯酰胺) (PNIPAM) 在水溶液中具有较低的临界溶解温度 (LCST) 行为，已被积极研究用于纳米技术和受控药物递送的各种应用。在这项工作中，用 PNIPAM 线圈和聚乙烯亚胺刷合成了梳状线圈嵌段共聚物。通过加热和随后的 PEI 电晕部分的交联，共聚物自组织成胶束，形成了一种独特的纳米胶囊 (i-CLM)，具有亲水性交联的 PEI 外壳和热响应 PNIPAM 内刷。纳米胶囊在室温下表现为囊泡状中空，但在加热时会变成胶束状球体。从动态光散射测量，显然，纳米胶囊在加热和冷却下表现出良好的可逆膨胀和收缩，并在较宽的温度响应范围内以渐进方式重复循环。以尼罗红（NR）的疏水荧光团为探针研究了纳米胶囊的载体性质，发现纳米胶囊的中空部分是一个很好的纳米袋，可以促进NR纳米晶体的生长。