Cryptococcosis by Cryptococcus gattii is endemic in Colombia, affecting mostly immunocompetent hosts. Since antifungal susceptibility differs between molecular types of cryptococcal isolates, as reported elsewhere, the aim of this study was to determine if 42 Colombian clinical isolates, VGI, VGII and VGIII, differ in the susceptibility to commonly used antifungals, using Sensititre plates. Among the molecular types, six non-wild type isolates to fluconazole, voriconazole, and 5-flucytosine, were identified. Besides, VGI and VGII were less susceptible to 5-flucytosine and azoles, respectively, than other molecular types. These findings support the applicability of practicing susceptibility testing, which could better guide treatment in cryptococcosis. Lay Summary Cryptococcosis gattii affects immunocompetent people. For a correct treatment, antifungal susceptibility testing is essential. This study shows differences in the susceptibility to commonly used antimycotics among genotypes of Colombian clinical C. gattii isolates, some of which are non-wild-type.

中文翻译：

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来自哥伦比亚的临床加特隐球菌分离株的抗真菌敏感性因分子类型而异

由加特隐球菌引起的隐球菌病在哥伦比亚流行，主要影响免疫能力强的宿主。由于隐球菌分离株分子类型的抗真菌敏感性不同，正如其他地方报道的那样，本研究的目的是确定 42 种哥伦比亚临床分离株，VGI、VGII 和 VGIII，使用 Sensititre 板对常用抗真菌剂的敏感性是否不同。在分子类型中，鉴定出六种非野生型分离株，分别为氟康唑、伏立康​​唑和 5-氟胞嘧啶。此外，VGI 和 VGII 对 5-氟胞嘧啶和唑类的敏感性分别低于其他分子类型。这些发现支持实践药敏试验的适用性，这可以更好地指导隐球菌病的治疗。总结 加特隐球菌病影响免疫能力强的人。为了正确的治疗，抗真菌药敏试验是必不可少的。这项研究显示了哥伦比亚临床 C. gattii 分离株的基因型对常用抗真菌剂的敏感性存在差异，其中一些是非野生型。