A measurement method suitable to investigate the melting behavior of solid mixtures in a high-pressure, co-solvent–modified CO₂ atmosphere was developed, using a variable volume, high-pressure view-cell. The solid sample is added after loading the organic solvents and pressurizing the cell with CO₂. Investigation of the melting behavior was done by a first-and-last melting point method at 16 MPa pressure. The melting point depression depended on the organic modifier (being acetonitrile or the 7:3 mixture of cyclohexane and isopropyl acetate). Adding acetonitrile in 2% to the carbon dioxide atmosphere shifted the chiral melting phase diagram of 3-chloromandelic acid by approx. 8–10 °C compared to the values measured earlier in pure carbon dioxide at the same pressure. The eutectic composition of the racemic compound remained unchanged (around 70–75% ee), which is comparable to the limiting composition observed in our earlier antisolvent recrystallization results aiming the enantiomeric purification of the model molecule.

开发了一种适合研究固体混合物在高压、共溶剂改性 CO ₂气氛中的熔化行为的测量方法，使用可变体积的高压观察室。在加载有机溶剂并用 CO ₂对池加压后加入固体样品. 在 16 MPa 压力下通过首末熔点法对熔化行为进行研究。熔点降低取决于有机改性剂（乙腈或环己烷和乙酸异丙酯的 7:3 混合物）。在二氧化碳气氛中加入 2% 的乙腈使 3-氯扁桃酸的手性熔融相图移动了大约 8–10 °C 与之前在相同压力下在纯二氧化碳中测得的值相比。外消旋化合物的共晶成分保持不变（约 70-75% ee），这与我们早期的抗溶剂重结晶结果中观察到的限制成分相当，旨在对模型分子的对映体纯化。