Understanding why proteins are overexpressed in cancer is of great interest, as it holds the potential for improved cancer diagnosis and treatment. A noteworthy candidate, p21-activated kinase 4 (PAK4), is frequently overexpressed in cancer and a key player in multiple hallmarks of cancer. Here we review findings backing PAK4 overexpression in cancer and motivate PAK4 as a suitable target for the development of cancer therapy.

中文翻译：

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为什么 PAK4 在癌症中过度表达？

了解蛋白质在癌症中过度表达的原因非常有趣，因为它具有改善癌症诊断和治疗的潜力。一个值得注意的候选者，p21 活化激酶 4 (PAK4)，经常在癌症中过度表达，并且是癌症多个标志的关键参与者。在这里，我们回顾了支持 PAK4 在癌症中过表达的发现，并促使 PAK4 作为开发癌症治疗的合适靶点。