Tin(IV) complexes of a 4-methylthiophenyl functionalized porphyrin (1-Sn) and its corrole analogue (2-Sn) were synthesized so that their photophysicochemical properties and photodynamic activities against MCF-7 breast cancer cells could be compared. Singlet oxygen luminescence studies revealed that 1-Sn and 2-Sn have comparable ΦΔ values in DMF of 0.59 and 0.60, respectively, while the IC50 values after irradiation of MCF-7 cells for 30 min with a Thorlabs 625 nm LED (432 J · cm−2) were determined to be 12.4 and 8.9 μM. The results demonstrate that the cellular uptake of 2-Sn and its molar absorptivity at the irradiation wavelength play a crucial role during in vitro cytotoxicity studies.

中文翻译：

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meso-4-methylthiophenyl 功能化 Sn(IV) tetraarylporphyrins 和 triarylcorroles 的光物理化学和光动力活性特性的比较研究

4-甲基噻吩官能化卟啉的锡 (IV) 配合物 (1-锡) 及其类似物 (2-锡) 被合成，以便可以比较它们对 MCF-7 乳腺癌细胞的光物理化学性质和光动力学活性。单线态氧发光研究表明，1-锡和2-锡有可比性ΦΔDMF 中的值分别为 0.59 和 0.60，而 IC50用 Thorlabs 625 nm LED (432 J·cm) 照射 MCF-7 细胞 30 分钟后的值-2)确定为 12.4 和 8.9μM. 结果表明，细胞摄取2-锡及其在辐照波长下的摩尔吸收率在体外细胞毒性研究。