Two novel water-soluble porphyrin-phosphonate conjugates were synthesized and characterized. Although both conjugates showed significant potential in photodynamic therapy, the variety of their structure induced the obvious differences in the binding manner with calf thymus DNA, the cytotoxicity and the cellular sublocalization.

中文翻译：

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水溶性卟啉-膦酸盐偶联物作为潜在的光动力治疗光敏剂

合成并表征了两种新型水溶性卟啉-膦酸盐偶联物。虽然这两种偶联物在光动力治疗中都显示出巨大的潜力，但它们的结构多样性导致与小牛胸腺DNA的结合方式、细胞毒性和细胞亚定位存在明显差异。