Astrocyte pathology is a feature of neuromyelitis optica spectrum disorder (NMOSD) pathology. Recently mitochondrial dysfunction and metabolic changes were suggested to play a role in NMOSD. To elucidate the role of mitochondrial dysfunction, astrocyte pathology was induced in C57BL/6 J female mice by intracerebral injection of aquaporin-4-immunoglobulin G from an NMOSD patient, together with complement. Etomoxir has been shown to cause mitochondrial dysfunction. Etomoxir was delivered to the central nervous system and resulted in decreased astrocyte pathology. The ameliorating effect was associated with increases in different acylcarnitines and amino acids. This suggests that mitochondria may be a therapeutic target in NMOSD.

星形胶质细胞病理学是视神经脊髓炎谱系障碍 (NMOSD) 病理学的一个特征。最近，有人认为线粒体功能障碍和代谢变化在 NMOSD 中起作用。为了阐明线粒体功能障碍的作用，通过脑内注射 NMOSD 患者的水通道蛋白-4-免疫球蛋白 G 和补体，在 C57BL/6 J 雌性小鼠中诱导星形胶质细胞病理学。Etomoxir 已被证明会导致线粒体功能障碍。Etomoxir 被输送到中枢神经系统并导致星形胶质细胞病理减少。改善效果与不同酰基肉碱和氨基酸的增加有关。这表明线粒体可能是 NMOSD 的治疗靶点。