Clinical and virological course of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center cohort study,Virology Journal

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Clinical and virological course of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center cohort study
Virology Journal ( IF 4.8 ) Pub Date : 2021-07-14 , DOI: 10.1186/s12985-021-01615-y
Rui Huang ₁ , Li Zhu ₂ , Leyang Xue ₃ , Xuebing Yan ₄ , Jian Wang ₁ , Songping Huang ₅ , Biao Zhang ₆ , Tianmin Xu ₇ , Fang Ji ₄ , Chunyang Li ₄ , Fang Ming ₅ , Yun Zhao ₈ , Yang Li ₉ , Juan Cheng ₁₀ , Yinling Wang ₂ , Huaping Shao ₁₁ , Shuqin Hong ₁₂ , Kang Chen ₁₃ , Xiang-An Zhao ₁₄ , Dawen Sang ₁₀ , Lei Zou ₁₀ , Haiyan Zhao ₁₁ , Xinying Guan ₁₅ , Xiaobing Chen ₁₆ , Biyun Xu ₁₇ , Juan Xia ₁ , Yuxin Chen ₁₈ , Xiaomin Yan ₁ , Jie Wei ₁₉ , Jiacheng Liu ₂₀ , Longgen Liu ₇ , Chuanwu Zhu ₂ , Chao Wu ₁

Affiliation

Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou, China.
Department of Critical Medicine, Huai'an No. 4 People's Hospital, Huai'an, China.
Department of Infectious Diseases, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Department of Infectious Diseases, Nantong Third People's Hospital, Nantong University, Nantong, China.
Department of Quality Control Office, Huai'an No. 4 People's Hospital, Huai'an, China.
Department of Infectious Diseases, The Third People's Hospital of Changzhou, Changzhou, China.
Department of Infectious Diseases, The Third People's Hospital of Yangzhou, Yangzhou, China.
Department of Infectious Diseases, Taizhou People's Hospital, Taizhou, China.
Department of Infectious Diseases, Yancheng Second People's Hospital, Yancheng, China.
Department of Infectious Diseases, The People's Hospital of Suqian, Suqian, China.
Nursing Department, Huai'an No. 4 People's Hospital, Huai'an, China.
Department of Tuberculosis, The Third People's Hospital of Changzhou, Changzhou, China.
Department of Gastroenterology, Northern Jiangsu People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, China.
Department of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang, China.
Department of Emergency, The Affiliated Hospital of Kangda College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang, China.
Department of Biostatistics, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

The clinical and virological course of patients with coronavirus disease 2019 (COVID-19) are lacking. We aimed to describe the clinical and virological characteristics of COVID-19 patients from 10 designated hospitals in 10 cities of Jiangsu province, China. The factors associated with the clearance of SARS-CoV-2 were investigated. A total of 328 hospitalized patients with COVID-19 were retrospectively recruited. The epidemiological, clinical, laboratory, radiology and treatment data were collected. The associated factors of SARS-CoV-2 clearance were analyzed. The median duration of hospitalization was 16.0 days (interquartile range [IQR] 13.0–21.0 days). On multivariate Cox regression analysis, age > 60 years (hazard ratio [HR] 0.643, 95% confidence interval [CI] 0.454–0.911, P = 0.013) was associated with the delayed SARS-CoV-2 clearance, while the atomized inhalation of interferon α-2b could improve the clearance of SARS-CoV-2 (HR, 1.357, 95% CI 1.050–1.755, P = 0.020). Twenty-six (7.9%) patients developed respiratory failure and 4 (1.2%) patients developed ARDS. Twenty (6.1%) patients were admitted to the ICU, while no patient was deceased. Our study found that age > 60 years was associated with the delayed SARS-CoV-2 clearance, while treated with atomized inhalation of interferon α-2b could promote the clearance of SARS-CoV-2.

更新日期：2021-07-14

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