Health disparities between American men of African and European descent (AA and EA, respectively) can be attributed to multiple factors, including disparities in socioeconomic status, access to healthcare, lifestyle, ancestry, and molecular aberrations. Numerous clinical trials and research studies are being performed to identify new and better therapeutic approaches to detect and treat prostate cancer. Of potential concern is the fact that the majority of the patients enrolled on these trials are EA. This disproportionate enrollment of EA could have implications when disease management recommendations are proposed without regard to the existing disparities in prostate cancer between races. With increasing advancements in immunotherapies, the immunological disparities between men of diverse ethnicities will need to be fully explored to develop novel and effective therapeutic approaches for prostate cancer patients globally. To help address this need, this review fully describes inequalities in prostate cancer at the immunological level between AA and EA.

美国非洲裔和欧洲裔男性（分别为 AA 和 EA）之间的健康差异可归因于多种因素，包括社会经济地位、医疗保健、生活方式、血统和分子畸变的差异。正在进行大量的临床试验和研究，以确定检测和治疗前列腺癌的新的和更好的治疗方法。潜在的担忧是，参加这些试验的大多数患者都是 EA。当提出疾病管理建议而不考虑种族之间前列腺癌的现有差异时，这种不成比例的 EA 注册可能会产生影响。随着免疫疗法的不断进步，需要充分探索不同种族男性之间的免疫差异，以便为全球前列腺癌患者开发新颖有效的治疗方法。为了帮助满足这一需求，本综述全面描述了前列腺癌在 AA 和 EA 免疫水平上的不平等。