Platelet-related measures are considered important in predicting long-term outcomes in patients with esophageal squamous cell carcinoma (ESCC).

We performed a systematic electronic research of studies evaluating the prognostic value of platelet-related measures in ESCC in Google Scholar, PubMed, Cochrane Library, and Embase. Then, to synthesize publications exploring the association between platelet-related measures and survival outcomes in ESCC, a meta-analysis was conducted using hazard ratio and 95 % confidence interval.

In total, 14 retrospective articles were included in this study. Among them, 4 and 10 have evaluated the clinical impact of platelet count and platelet-to-lymphocyte ratio (PLR), respectively. Further, three studies reported about platelet distribution width (PDW) and mean platelet volume (MPV). Based on the synthesized results, high PLR was significantly associated with poor overall survival (OS). However, platelet count, PDW, and MPV were non-independent prognostic factors for OS. The Begg’s funnel plots for PLR, PDW, and MPV indicated low publication bias.

血小板相关指标被认为在预测食管鳞状细胞癌 (ESCC) 患者的长期预后方面很重要。

我们对 Google Scholar、PubMed、Cochrane Library 和 Embase 中评估 ESCC 中血小板相关指标预后价值的研究进行了系统的电子研究。然后，为了综合探索 ESCC 中血小板相关指标与生存结果之间关联的出版物，使用风险比和 95% 置信区间进行了荟萃分析。

本研究共纳入 14 篇回顾性文章。其中，4 和 10 分别评估了血小板计数和血小板与淋巴细胞比 (PLR) 的临床影响。此外，三项研究报告了血小板分布宽度 (PDW) 和平均血小板体积 (MPV)。根据综合结果，高PLR与较差的总生存期（OS）显着相关。然而，血小板计数、PDW 和 MPV 是 OS 的非独立预后因素。PLR、PDW 和 MPV 的 Begg 漏斗图表明发表偏倚较低。