The molar activity of [¹⁸F]fluoride was determined by HPLC of sulfonyl fluorides, which have high UV absorbance and are formed exclusively from sulfonyl chlorides and [¹⁸F]fluoride in aqueous solution. The measurable limit of sulfonyl fluorides is as low as 0.1 ppm, allowing measurements up to the theoretical molar activity of [¹⁸F]fluoride. The method was validated with standard solutions of fluoride, and provides a convenient way to measure molar activity of [¹⁸F]fluoride using only HPLC without specialized equipment.

中文翻译：

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[18F]氟化物的摩尔活性通过磺酰基衍生化的HPLC测定

[ ¹⁸ F]氟化物的摩尔活性通过磺酰氟的HPLC测定，磺酰氟具有高UV吸收并且仅由磺酰氯和[ ¹⁸ F]氟化物在水溶液中形成。磺酰氟的可测量限值低至 0.1 ppm，允许测量高达 [ ¹⁸ F] 氟化物的理论摩尔活性。该方法用氟化物的标准溶液进行了验证，并提供了一种方便的方法来测量 [ ¹⁸ F] 氟化物的摩尔活性，无需专门的设备即可仅使用 HPLC。