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Cardiovascular responses to low-level transcutaneous vagus nerve stimulation
Autonomic Neuroscience ( IF 2.7 ) Pub Date : 2021-07-14 , DOI: 10.1016/j.autneu.2021.102851
Matjaz Sinkovec 1 , Roman Trobec 2 , Bernard Meglic 3
Affiliation  

Aims

The aim was to determine cardiovascular responses to an arbitrary protocol of transcutaneous low-level vagus nerve electrical stimulation (tVNS).

Methods

Study was performed in 15 male volunteers, mean age 23 years. Data were collected during two sessions – sham stimulation (no stimulation) and stimulation. Each session included one-hour resting phase followed by 15-min autonomic nervous system testing phase (Valsalva, deep breathing, wet-cold face tests), all in supine position. The right tragus stimulation parameters were: 20 Hz, constant current at sensation threshold, 1 ms rectangular pulse width. The ECG, noninvasive arterial blood pressure and thoracic impedance cardiography measurements were recorded and analyzed continuously with the Task Force® Monitor (CNSystems Medizintechnik GmbH, Graz, Ver. 2.2.10.0). t-Test for paired samples, paired Wilcoxon signed-rank, and one-way ANOVA for repeated measurements were carried out. P < 0.05 was considered significant.

Results

We demonstrated significant reductions of left ventricular contractility and output parameters, a trend for heart rate reduction, and resulting beneficial reduction of left ventricular work load. However, significant increases of blood pressure and total peripheral resistance were recognized, possibly as a reflex response.

Conclusion

It seems that our tVNS protocol has a potential for cardiac autonomic modulation. This gives us opportunity to advance our stimulation parameters with participant-specific adjustments. Further studies are however needed to prove the therapeutic potential of such approach in different patient groups.



中文翻译:

对低水平经皮迷走神经刺激的心血管反应

宗旨

目的是确定对经皮低水平迷走神经电刺激 (tVNS) 的任意方案的心血管反应。

方法

研究在 15 名男性志愿者中进行,平均年龄 23 岁。在两个会话期间收集数据 - 假刺激(无刺激)和刺激。每次训练都包括 1 小时的休息阶段,然后是 15 分钟的自主神经系统测试阶段(Valsalva、深呼吸、湿冷面部测试),全部处于仰卧位。右耳屏刺激参数为:20 Hz,感觉阈值恒定电流,1 ms 矩形脉冲宽度。使用 Task Force® Monitor (CNSystems Medizintechnik GmbH, Graz, Ver. 2.2.10.0) 连续记录和分析心电图、无创动脉血压和胸阻抗心动图测量值。进行了配对样本的t检验、配对 Wilcoxon 符号秩和用于重复测量的单向方差分析。 < 0.05 被认为是显着的。

结果

我们证明了左心室收缩力和输出参数的显着降低、心率降低的趋势以及由此产生的左心室工作负荷的有益降低。然而,血压和总外周阻力的显着增加被认为是一种反射反应。

结论

看来我们的 tVNS 协议具有心脏自主调节的潜力。这使我们有机会通过特定于参与者的调整来提高我们的刺激参数。然而,需要进一步的研究来证明这种方法在不同患者群体中的治疗潜力。

更新日期:2021-07-15
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