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Population-based surveillance of Enterobacter cloacae complex causing blood stream infections in a centralized Canadian region
European Journal of Clinical Microbiology & Infectious Diseases ( IF 4.5 ) Pub Date : 2021-07-14 , DOI: 10.1007/s10096-021-04309-z
William Stokes 1, 2, 3, 4 , Gisele Peirano 1, 2 , Yasufumi Matsumara 5 , Diego Nobrega 6 , Johann D D Pitout 1, 2, 7
Affiliation  

Active population-based surveillance determined clinical factors, susceptibility patterns, incidence rates (IR), and genomics among Enterobacter cloacae complex (n = 154) causing blood stream infections in a centralized Canadian region (2015–2017). The annual population IR was 1.2/100,000 (95% CI 0.9–16) in 2015, 1.4/100,000 (95% CI 1.1–1.9) in 2016, and 1.5/100,000 (95% CI 1.2–2.0) in 2017, affecting mainly elderly males with underlying comorbid conditions in the hospital setting. E. cloacae complex was dominated by polyclonal subspecies (i.e., E. hormaechei subsp. steigerwaltii, subsp. hoffmanni and subsp. xiangfangesis). Antimicrobial resistant determinants were rare. This study provided novel information about Enterobacter genomics in a well-defined human population.



中文翻译:

在加拿大中部地区对引起血流感染的阴沟肠杆菌群进行基于人群的监测

 基于人群的主动监测确定了导致加拿大中部地区(2015-2017 年)血流感染的阴沟肠杆菌复合体(n = 154)的临床因素、易感性模式、发病率(IR)和基因组学。2015 年年人口 IR 为 1.2/100,000 (95% CI 0.9–16),2016 年为 1.4/100,000 (95% CI 1.1–1.9),2017 年为 1.5/100,000 (95% CI 1.2–2.0),主要影响在医院环境中患有潜在合并症的老年男性。E. cloacae complex 以多克隆亚种为主(即E. hormaechei subsp. steigerwaltii、 subsp. hoffmanni和 subsp. xiangfangesis)。抗生素耐药性决定因素很少见。这项研究提供了有关明确人群中肠杆菌基因组学的新信息。

更新日期:2021-07-14
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