HIV is a virus that remains a major health concern and results in an infection that has no cure even after over 30 years since its discovery. As such, HIV vaccine discovery continues to be an area of intensive research. In this review, we summarize the most recent HIV vaccine efficacy trials, clinical trials initiated within the last 3 years, and discuss prominent improvements that have been made in prophylactic HIV vaccine designs.

中文翻译：

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HIV 疫苗学：2021 年更新

HIV 是一种仍然是主要健康问题的病毒，其导致的感染即使在发现 30 多年后仍无法治愈。因此，艾滋病毒疫苗的发现仍然是一个深入研究的领域。在这篇综述中，我们总结了最近的 HIV 疫苗功效试验、过去 3 年内启动的临床试验，并讨论了预防性 HIV 疫苗设计方面取得的显着改进。