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Adenosine A2a receptors modulate TrkB receptor-dependent respiratory plasticity in neonatal rats
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-07-14 , DOI: 10.1016/j.resp.2021.103743
Stephen M Johnson 1 , Ranveer M S Vasdev 1 , McKayla M Miller 1 , Tracy L Baker 1 , Jyoti J Watters 1
Affiliation  

Neuroplasticity is a fundamental property of the respiratory control system, enabling critical adaptations in breathing to meet the challenges, but little is known whether neonates express neuroplasticity similar to adults. We tested the hypothesis that, similar to adults, tyrosine receptor kinase B (TrkB) or adenosine A2a receptor activation in neonates are independently sufficient to elicit respiratory motor facilitation, and that co-induction of TrkB and A2a receptor-dependent plasticity undermines respiratory motor facilitation. TrkB receptor activation with 7,8-dihydroxyflavone (DHF) in neonatal brainstem-spinal cord preparations induced a long-lasting increase in respiratory motor output in 55 % of preparations, whereas adenosine A2a receptor activation with CGS21680 only sporadically induced respiratory motor plasticity. CGS21680 and DHF co-application prevented DHF-dependent respiratory motor facilitation, whereas co-application of MSX-3 (adenosine A2a receptor antagonist) and DHF more rapidly induced respiratory motor plasticity. Collectively, these data suggest that mechanisms underlying respiratory neuroplasticity may be only partially operational in early neonatal life, and that adenosine A2a receptor activation undermines TrkB-induced respiratory plasticity.



中文翻译:

腺苷 A2a 受体调节新生大鼠 TrkB 受体依赖性呼吸可塑性

神经可塑性是呼吸控制系统的一个基本特性,使呼吸的关键适应能够应对挑战,但鲜为人知的是新生儿是否表现出与成人相似的神经可塑性。我们测试了以下假设:与成人相似,新生儿的酪氨酸受体激酶 B (TrkB) 或腺苷 A2a 受体激活独立足以引发呼吸运动促进,并且 TrkB 和 A2a 受体依赖性可塑性的共同诱导破坏呼吸运动促进. 在新生儿脑干-脊髓标本中,用 7,8-二羟基黄酮 (DHF) 激活 TrkB 受体可导致 55% 标本中呼吸运动输出的长期增加,而用 CGS21680 激活腺苷 A2a 受体只会偶尔诱导呼吸运动可塑性。CGS21680 和 DHF 共同应用阻止了 DHF 依赖性呼吸运动促进,而 MSX-3(腺苷 A2a 受体拮抗剂)和 DHF 共同应用更迅速地诱导呼吸运动可塑性。总的来说,这些数据表明呼吸神经可塑性的潜在机制可能仅在新生儿早期部分起作用,并且腺苷 A2a 受体激活会破坏 TrkB 诱导的呼吸可塑性。

更新日期:2021-07-15
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