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α-d-Glucofuranose and α-d-allofuranose diacetonides and silyl ether of α-d-glucofuranose diacetonide in dithiophosphorylation reactions
Heteroatom Chemistry ( IF 0.3 ) Pub Date : 2016-09-09 , DOI: 10.1002/hc.21344
Ilyas S. Nizamov 1, 2 , Yevgeniy N. Nikitin 1 , Ilnar D. Nizamov 1 , Timur G. Belov 1 , Alexandra D. Voloshina 2 , Elvira S. Batyeva 2 , Rafael A. Cherkasov 1
Affiliation  

α-d-Glucofuranose and α-d-allofuranose diacetonides react with 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides to form optically active dithiophosphonates in 78–81% yields, which are transformed into the corresponding ammonium salts in 90–97% yields by the treatment of n-hexadecylamine. The S-silyldithiophosphonate was prepared in 93% yield by the reaction of 2,4-bis(butoxyphenyl) 1,3,2,4-dithiadiphosphetane-2,4-disulfide with silyl ether of α-d-glucofuranose diacetonide. One of the salts obtained possesses antibacterial activity against Staphylococcus aureus ATCC 6538-P.

中文翻译:

α-d-呋喃葡萄糖和α-d-异呋喃糖二丙酮化物以及α-d-呋喃葡萄糖二丙酮化物在二硫代磷酸化反应中的甲硅烷基醚

α-d-呋喃葡萄糖和 α-d-异呋喃糖二丙酮化物与 2,4-二有机基 1,3,2,4-dithiadiphosphetane-2,4-disulfides 反应生成光学活性二硫代膦酸酯,产率为 78-81%,转化为通过正十六胺的处理,相应的铵盐的产率为 90-97%。S-甲硅烷基二硫代膦酸酯通过 2,4-双(丁氧基苯基)1,3,2,4-二硫代二膦烷-2,4-二硫化物与 α-d-呋喃葡萄糖二丙酮化物的甲硅烷基醚反应制备,产率为 93%。获得的盐之一对金黄色葡萄球菌 ATCC 6538-P 具有抗菌活性。
更新日期:2016-09-09
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