Efficacy of S-1 after pemetrexed in patients with non-small cell lung cancer: A retrospective multi-institutional analysis,Thoracic Cancer

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Efficacy of S-1 after pemetrexed in patients with non-small cell lung cancer: A retrospective multi-institutional analysis
Thoracic Cancer ( IF 2.9 ) Pub Date : 2021-07-13 , DOI: 10.1111/1759-7714.14055
Shinnosuke Takemoto ₁ , Kazumasa Akagi ₂ , Sawana Ono ₃ , Hiromi Tomono ₄ , Noritaka Honda ₁ , Takayuki Suyama ₁ , Yasuhiro Umeyama ₁ , Yosuke Dotsu ₁ , Hirokazu Taniguchi ₅ , Daiki Ogawara ₆ , Hiroaki Senju ₇ , Hiroshi Gyotoku ₁ , Nanae Sugasaki ₈ , Hiroyuki Yamaguchi ₁ , Katsumi Nakatomi ₉ , Minoru Fukuda ₁₀ , Hiroshi Mukae ₁

Affiliation

Department of Respiratory Medicine, Nagasaki University Graduate, School of Biomedical Sciences, Nagasaki, Japan.
Department of Respiratory Medicine, Japanese Red Cross Nagasaki Genbaku Isahaya Hospital, Nagasaki, Japan.
Department of Respiratory Medicine, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.
Department of Respiratory Medicine, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
Molecular Pharmacology Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Respiratory Medicine, Fukuoka Wajiro Hospital, Fukuoka, Japan.
Department of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Department of Respiratory Medicine, Nagasaki Prefecture Shimabara Hospital, Nagasaki, Japan.
Department of Respiratory Medicine, National Hospital Organization Ureshino Medical Center, Saga, Japan.
Department of Clinical oncology Center, Nagasaki University Hospital, Nagasaki, Japan.

S-1 and pemetrexed (PEM) are key treatments for non-small cell lung cancer (NSCLC). However, the mechanism of anticancer activity of S-1 and PEM is similar. Cross-resistance between S-1 and PEM is of concern. This exploratory study was designed to evaluate the treatment effect of S-1 following PEM-containing treatment.

中文翻译：

培美曲塞后S-1对非小细胞肺癌患者的疗效：一项回顾性多机构分析

S-1 和培美曲塞 (PEM) 是非小细胞肺癌 (NSCLC) 的关键治疗方法。然而，S-1 和 PEM 的抗癌活性机制是相似的。S-1 和 PEM 之间的交叉耐药性值得关注。这项探索性研究旨在评估 S-1 在含 PEM 治疗后的治疗效果。

更新日期：2021-09-02

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