The multifunctional transcription factor TFII-I, encoded by the GTF2I gene, is implicated in various biological pathways, and associated with multiple human disorders. Evidence is also mounting to suggest that TFII-I is involved in DNA damage repair pathways. Here I bring together these recent observations and suggest a connection between transcriptional and DNA repair functions of TFII-I.

中文翻译：

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多功能转录因子TFII-I在DNA损伤修复中的作用

由GTF2I基因编码的多功能转录因子 TFII-I涉及多种生物学途径，并与多种人类疾病有关。越来越多的证据表明 TFII-I 参与 DNA 损伤修复途径。在这里，我汇总了这些最近的观察结果，并提出了 TFII-I 的转录和 DNA 修复功能之间的联系。