Poor growth is a common finding in children with chronic kidney disease (CKD) that has been associated with poor long-term outcomes. The etiology of poor growth in this population is multifactorial and includes dysregulation of the growth hormone (GH) and insulin-like growth factor (IGF) axis. In this review, we describe the data on GH resistance or insensitivity and inappropriate levels or reduced bioactivity of IGF proposed as contributing factors of growth impairment in children with CKD. Additionally, we describe the theorized negative effect of metabolic acidosis, another frequent finding in pediatric CKD, on the GH/IGF axis and growth. Last, we present the current and potential therapies for the treatment of short stature in pediatric CKD that target the GH/IGF hormonal axis.
Horm Res Paediatr

中文翻译：

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小儿慢性肾脏病中的生长激素和胰岛素样生长因子失调

生长不良是慢性肾脏病 (CKD) 儿童的常见发现，与长期预后不良有关。该人群生长不良的病因是多因素的，包括生长激素 (GH) 和胰岛素样生长因子 (IGF) 轴的失调。在这篇综述中，我们描述了有关 GH 抗性或不敏感以及 IGF 水平不当或生物活性降低的数据，这些数据被认为是 CKD 儿童生长障碍的促成因素。此外，我们描述了代谢性酸中毒（儿童 CKD 中的另一个常见发现）对 GH/IGF 轴和生长的理论上的负面影响。最后，我们介绍了针对 GH/IGF 激素轴的小儿 CKD 身材矮小治疗的当前和潜在疗法。
儿科荷尔蒙