Enzyme-catalysis-mediated reversible addition-fragmentation chain transfer (Enz-RAFT) polymerization is considered to be one of the most versatile synthetic strategies and biotechnologies, proceeding in an efficient, mild, and selective manner. Benefiting from its benignity, high efficiency, and eco-friendliness, Enz-RAFT has been widely applied in various fields, such as precise, multi-block copolymers; ultrahigh molecular weight (UHMW) polymers; functional polymers with complex architectures; and well-defined polymers. Different from other new RAFT polymerization techniques (e.g., metal-, photo-, redox-, photoinduced electron/energy transfer [PET]-, etc.), Enz-RAFT can initiate RAFT polymerization under ambient conditions, particularly controlling the RAFT process even in the present of oxygen, which has attracted much attention. This review summarizes current advances in Enz-RAFT polymerization for functional applications.

酶催化介导的可逆加成断裂链转移 (Enz-RAFT) 聚合被认为是最通用的合成策略和生物技术之一，以高效、温和和选择性的方式进行。得益于其良性、高效、环保等优点，Enz-RAFT在精密、多嵌段共聚物等领域得到了广泛的应用；超高分子量 (UHMW) 聚合物；具有复杂结构的功能聚合物；和定义明确的聚合物。与其他新的 RAFT 聚合技术（例如，金属-、光-、氧化还原-、光致电子/能量转移 [PET]- 等）不同，Enz-RAFT 可以在环境条件下引发 RAFT 聚合，特别是控制 RAFT 过程甚至在氧气的存在下，这引起了很多关注。