A new diterpenoid, 15,16,17-trihydroxy,18-carboxylic acid 18-neo-clerodan-3,13-(Z)-diene was isolated from Sheareria nana S. Moore. The structure was elucidated by spectroscopic data. Compound 1 was evaluated for cytotoxic activities against human endometrial carcinoma cells (ECC-1). The results indicated that 1 showed moderate cytotoxic activity against ECC-1 cell lines with IC₅₀ values of 5.6 ± 0.3 and 2.2 ± 0.2 μM for 24 and 48 h, respectively. Taken together, 1 was a good choice for the treatment of endometrial carcinoma.

中文翻译：

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来自 Sheareria nana 的抗子宫内膜癌的新二萜

从 Sheareria nana S. Moore 中分离出一种新的二萜类化合物，15,16,17-trihydroxy,18-羧酸 18-neo-clerodan-3,13-(Z)-diene。通过光谱数据阐明了结构。评估了化合物1对人子宫内膜癌细胞 (ECC-1) 的细胞毒活性。结果表明，1对 ECC-1 细胞系显示出中等的细胞毒活性，24 小时和 48 小时的IC ₅₀值分别为 5.6 ± 0.3 和 2.2 ± 0.2 μM。综合来看，1是治疗子宫内膜癌的不错选择。