Mesenchymal stem cells (MSCs) are a population of primary and non-specialized cells, which can be isolated from various tissues. Currently, MSCs are key players in cellular therapy and regenerative medicine. However, the possibility of using MSCs in the treatment of many diseases needs to be preceded, though, by in-depth analysis of their properties, especially by determining the mechanism of tissue homing as well as the mechanism, due to which cells contribute to tissue regeneration. This review is intended to present information on recent findings regarding the mechanism of recruitment and tissue homing by MSCs and discuss current hypotheses for how MSCs can reach target tissues.

中文翻译：

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调节间充质干细胞迁移和归巢的生物、化学和机械因素。

间充质干细胞 (MSCs) 是一群原代和非特化细胞，可以从各种组织中分离出来。目前，MSCs 是细胞治疗和再生医学的关键参与者。然而，在使用 MSCs 治疗许多疾病的可能性之前，需要对其特性进行深入分析，特别是通过确定组织归巢的机制以及机制，由于哪些细胞有助于组织再生。本综述旨在提供有关 MSC 募集和组织归巢机制的最新发现的信息，并讨论有关 MSC 如何到达目标组织的当前假设。