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Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells.
World Journal of Stem Cells ( IF 4.1 ) Pub Date : 2021-7-13 , DOI: 10.4252/wjsc.v13.i6.659
Mujib Ullah 1 , Nicole Pek Min Qian 2 , Gustavo Yannarelli 3 , Asma Akbar 4
Affiliation  

Heat shock proteins (HSPs) are molecular chaperones that protect cells against cellular stresses or injury. However, it has been increasingly recognized that they also play crucial roles in regulating fundamental cellular processes. HSP20 has been implicated in cell proliferation, but conflicting studies have shown that it can either promote or suppress proliferation. The underlying mechanisms by which HSP20 regulates cell proliferation and pluripotency remain unexplored. While the effect of HSP20 on cell proliferation has been recognized, its role in inducing pluripotency in human-induced pluripotent stem cells (iPSCs) has not been addressed.

中文翻译:

热休克蛋白 20 促进诱导多能干细胞中的沉默调节蛋白 1 依赖性细胞增殖。

热休克蛋白 (HSP) 是保护细胞免受细胞压力或损伤的分子伴侣。然而,人们越来越认识到它们在调节基本细胞过程中也起着至关重要的作用。HSP20 与细胞增殖有关,但相互矛盾的研究表明它可以促进或抑制增殖。HSP20 调节细胞增殖和多能性的潜在机制仍未探索。虽然已经认识到 HSP20 对细胞增殖的影响,但其在诱导人诱导多能干细胞 (iPSC) 多能性中的作用尚未得到解决。
更新日期:2021-07-14
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