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Manufacture of non-thrombogenic polymer surfaces by gamma irradiation to induce simultaneous grafting and heparinization of thin PVC films
Journal of Bioactive and Compatible Polymers ( IF 1.7 ) Pub Date : 2021-07-12 , DOI: 10.1177/08839115211030634
Luz Consuelo Gonzalez Alonso Panzarini 1, 2 , Andreia de Araújo Morandim-Giannetti 1 , Selma Matheus Loureiro Guedes 2
Affiliation  

Investigations regarding alternative methods for producing polymeric materials with hydrophilic properties have increased considerably. In this context, polymeric biomaterials with hemocompatible surface properties have been successfully obtained by grafting hydrophilic monomers onto commercial polymer films by simultaneous irradiation processes. In this study, simultaneous irradiation and grafting were used to produce a copolymer PVC-co-DMAEMA-co-heparin with hemocompatible surface properties. Characterization by FTIR of the graft copolymer indicates that the increase in monomer grafting levels inhibits the bonding sites to heparin. FTIR-PAS analyses of the graft copolymers showed that the highest graft levels were obtained for the irradiated samples containing 45% of monomer. Heparin, however, could only be detected in the irradiated samples containing 30% of DMAEMA. The analysis of the micrographs, on the other hand, showed that increasing the monomer concentration enhances surface roughness of the graft copolymers. Roughness however decreased with heparin addition. It was possible to verify that an excess of surface roughness of the graft copolymers inhibits anticoagulant properties of heparin, triggering thrombus formation. Platelet adhesion, on its turn, was not significantly affected by the presence of heparin when PVC-co-DMAEMA and PVC-co-DMAEMA-co-heparin, obtained from the systems containing 45% of monomer, are compared. The addition of heparin in the systems containing 30% of DMAEMA resulted in fewer thrombogenic surfaces.



中文翻译:

通过伽马辐射制造非血栓形成聚合物表面以诱导 PVC 薄膜的同时接枝和肝素化

关于生产具有亲水特性的聚合物材料的替代方法的研究已大大增加。在这种情况下,通过同步辐照工艺将亲水单体接枝到商业聚合物薄膜上,已成功获得具有血液相容性表面特性的聚合物生物材料。在这项研究中,同时照射和接枝被用来生产共聚物 PVC-co-DMAEMA-co-heparin 具有血液相容性表面特性。接枝共聚物的 FTIR 表征表明单体接枝水平的增加抑制了与肝素的结合位点。接枝共聚物的 FTIR-PAS 分析表明,含有 45% 单体的辐照样品获得了最高的接枝水平。然而,肝素 只能在含有 30% DMAEMA 的辐照样品中检测到。另一方面,显微照片的分析表明,增加单体浓度会提高接枝共聚物的表面粗糙度。然而,粗糙度随着肝素的加入而降低。有可能证实接枝共聚物的过度表面粗糙度会抑制肝素的抗凝特性,从而引发血栓形成。反过来,当比较从含有 45% 单体的系统中获得的 PVC-co-DMAEMA 和 PVC-co-DMAEMA-co-heparin 时,血小板粘附不受肝素存在的显着影响。在含有 30% DMAEMA 的系统中添加肝素导致血栓形成表面更少。表明增加单体浓度会提高接枝共聚物的表面粗糙度。然而,粗糙度随着肝素的加入而降低。有可能证实接枝共聚物的过度表面粗糙度会抑制肝素的抗凝特性,从而引发血栓形成。反过来,当比较从含有 45% 单体的系统中获得的 PVC-co-DMAEMA 和 PVC-co-DMAEMA-co-heparin 时,血小板粘附不受肝素存在的显着影响。在含有 30% DMAEMA 的系统中添加肝素导致血栓形成表面更少。表明增加单体浓度会提高接枝共聚物的表面粗糙度。然而,粗糙度随着肝素的加入而降低。有可能证实接枝共聚物的过度表面粗糙度会抑制肝素的抗凝特性,从而引发血栓形成。反过来,当比较从含有 45% 单体的系统中获得的 PVC-co-DMAEMA 和 PVC-co-DMAEMA-co-heparin 时,血小板粘附不受肝素存在的显着影响。在含有 30% DMAEMA 的系统中添加肝素导致血栓形成表面更少。有可能证实接枝共聚物的过度表面粗糙度会抑制肝素的抗凝特性,从而引发血栓形成。反过来,当比较从含有 45% 单体的系统中获得的 PVC-co-DMAEMA 和 PVC-co-DMAEMA-co-heparin 时,血小板粘附不受肝素存在的显着影响。在含有 30% DMAEMA 的系统中添加肝素导致血栓形成表面更少。有可能证实接枝共聚物的过度表面粗糙度会抑制肝素的抗凝特性,从而引发血栓形成。反过来,当比较从含有 45% 单体的系统中获得的 PVC-co-DMAEMA 和 PVC-co-DMAEMA-co-heparin 时,血小板粘附不受肝素存在的显着影响。在含有 30% DMAEMA 的系统中添加肝素导致血栓形成表面更少。

更新日期:2021-07-13
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