Generation of plasma cells and CD27−IgD− B cells during hantavirus infection is associated with distinct pathological findings,Clinical & Translational Immunology

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Generation of plasma cells and CD27−IgD− B cells during hantavirus infection is associated with distinct pathological findings
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2021-07-12 , DOI: 10.1002/cti2.1313
Priscilla F Kerkman ₁ , Andy Dernstedt ₁ , Lalitha Tadala _{2,

3} , Eva Mittler ₄ , Mirjam Dannborg _{2,

3} , Christopher Sundling _{5,

6} , Kimia T Maleki ₇ , Johanna Tauriainen ₇ , Anne Tuiskunen-Bäck ₁ , Julia Wigren Byström ₁ , Pauline Ocaya ₁ , Therese Thunberg ₁ , Rohit K Jangra ₄ , Gleyder Román-Sosa ₈ , Pablo Guardado-Calvo ₈ , Felix A Rey ₈ , Jonas Klingström ₇ , Kartik Chandran ₄ , Andrea Puhar _{2,

3} , Clas Ahlm ₁ , Mattias Ne Forsell ₁

Affiliation

Human hantavirus infections can cause haemorrhagic fever with renal syndrome (HFRS). The pathogenic mechanisms are not fully understood, nor if they affect the humoral immune system. The objective of this study was to investigate humoral immune responses to hantavirus infection and to correlate them to the typical features of HFRS: thrombocytopenia and transient kidney dysfunction.

中文翻译：

汉坦病毒感染期间浆细胞和 CD27-IgD-B 细胞的生成与不同的病理结果相关

人类汉坦病毒感染可引起肾综合征出血热 (HFRS)。致病机制尚不完全清楚，它们是否会影响体液免疫系统。本研究的目的是研究对汉坦病毒感染的体液免疫反应，并将其与 HFRS 的典型特征相关联：血小板减少和短暂的肾功能障碍。

更新日期：2021-07-13

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