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Recent advances in herbal combination nanomedicine for cancer: delivery technology and therapeutic outcomes
Expert Opinion on Drug Delivery ( IF 6.6 ) Pub Date : 2021-08-04 , DOI: 10.1080/17425247.2021.1955853
Doaa M. Anwar, Mousa El-Sayed, Asmaa Reda, Jia-You Fang, Sherine N. Khattab, Ahmed O. Elzoghby

ABSTRACT

Introduction: The use of herbal compounds in cancer therapy has great potential to promote the efficacy of current cancer therapeutic strategies. Herbal compounds were successfully reported to enhance tumor cells sensitization to the action of chemo-, hormonal- and gene-therapeutic agents via different mechanisms. Herbal ingredients can affect different signaling pathways, reduce the toxic side effects or inhibit the efflux of anticancer drugs.

Areas covered: This review will discuss the delivery of herbal compounds with other cancer treatments such as hormonal, small molecule inhibitors and inorganic hybrids to tumor cells. An overview of physicochemical properties of herbal components that require intelligent design of combo-nanomedicines for efficient co-delivery of those herbal-derived and other anticancer agents was discussed. Nanocarriers provide various benefits to overcome the shortcomings of the encapsulated herbal compounds including improved solubility, increased stability and enhanced tumor targeting. Different nanocarrier systems were the focus of this review.

Expert opinion: Multifunctional nanocarrier systems encapsulating herbal and different anticancer drugs showed to be a wonderful approach in the treatment of cancer enabling the co-delivery of anticancer drugs with versatile modes of action in an accurate manner in an attempt to enhance the efficacy, benefit from the synergism between the drugs as well as to minimize the development of multi-drug resistance. The main challenge point is the early detection and management of any developed adverse effect.



中文翻译:

用于癌症的草药组合纳米药物的最新进展:递送技术和治疗结果

摘要

简介:在癌症治疗中使用草药化合物具有提高当前癌症治疗策略功效的巨大潜力。据报道,草药化合物可通过不同机制增强肿瘤细胞对化学、激素和基因治疗剂作用的敏感性。草药成分可以影响不同的信号通路,减少毒副作用或抑制抗癌药物的外排。

涵盖的领域:本综述将讨论将草药化合物与其他癌症治疗方法(如激素、小分子抑制剂和无机杂化物)输送到肿瘤细胞。讨论了草药成分的理化特性的概述,这些成分需要智能设计组合纳米药物,以便有效地共同递送这些草药衍生的和其他抗癌剂。纳米载体提供各种好处来克服封装的草药化合物的缺点,包括提高溶解度、增加稳定性和增强肿瘤靶向性。不同的纳米载体系统是本次审查的重点。

专家意见: 多功能纳米载体系统封装草药和不同的抗癌药物被证明是一种治疗癌症的绝妙方法,能够以准确的方式共同递送具有多种作用模式的抗癌药物,以提高疗效,受益于药物之间的协同作用以及尽量减少多药耐药性的发展。主要挑战点是及早发现和管理任何已产生的不利影响。

更新日期:2021-08-04
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