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Isolation and Characterization of Hepatoprotective Anthraquinone Derivatives from Cucumis bisexualis
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2021-07-12 , DOI: 10.1007/s10600-021-03437-4
Qinge Ma 1 , Rongrui Wei 1
Affiliation  

A new anthraquinone, named 1,3-dihydroxy-2-methylene-(1′-isopentyloxy)-6-methoxymethyl-8-(6′′,7′′,8′′- trihydroxyphenylketonyl)-9,10-anthraquinone (1), and nine known anthraquinone derivatives (2–10), were isolated from Cucumis bisexualis for the first time. Compounds 1–10 were evaluated for their hepatoprotective activity in human L-O2 cells compared with the positive control bifendatatum. Among them, compounds 1, 3, and 8 exhibited moderate hepatoprotective activity in the proliferation of L-O2 cells.



中文翻译:

双性黄瓜保肝蒽醌衍生物的分离与表征

一种新的蒽醌,命名为1,3-二羟基-2-亚甲基-(1'-异戊氧基)-6-甲氧基甲基-8-(6'',7'',8''-三羟基苯基酮基)-9,10-蒽醌( 1 ) 和九种已知的蒽醌衍生物 ( 2–10 ) 是首次从双性黄瓜中分离得到。与阳性对照联苯双歧杆菌相比,评估了化合物1-10在人 L-O2 细胞中的保肝活性。其中,化合物138中L-O2细胞的增殖显示出适度的保肝活性。

更新日期:2021-07-12
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